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AI Biotech/Diagnostics: Cardio
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Application US20190328457
Published 2019-10-31
Identify Ablation Pattern For Use In An Ablation
Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration. The systems may generate a cardiogram for each source configuration from the modeled electromagnetic output of that source configuration for use in predicting the source location of an arrhythmia.
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- 1. A method performed by one or more computing systems for identifying a potential ablation pattern for an electromagnetic (“EM”) source of a patient, the method comprising:
accessing a patient EM output of the EM source; identifying non-ablation pattern information of a non-ablation pattern simulation, the non-ablation pattern information being identified based on similarity of simulated EM output of the non-ablation pattern simulation to the patient EM output; identifying an ablation pattern based on similarity of non-ablation pattern information to ablation pattern information associated with an ablation pattern simulation; and outputting an indication of the identified ablation pattern as the potential ablation pattern for the EM source of the patient.
- 14. A method performed by one or more computing systems for generating a mapping function to map patient information of a patient to an ablation pattern for treating arrhythmia of the patient, the method comprising:
accessing ablation pattern simulations, each ablation pattern simulation generated based on a simulated source configuration and an ablation pattern, the simulated source configuration including a simulated source location; for each ablation pattern simulation,
generating a simulated feature vector that includes features based on the simulated source configuration but not based on the simulated source location and a feature based on a simulated cardiogram generated from a non-ablation pattern simulation based on the simulated source configuration but not based on an ablation pattern; and
labeling the simulated feature vector with the simulated source location and the ablation pattern of that ablation pattern simulation; and
training a classifier using the feature vectors and labels as training data.
- 18. One or more computing systems for identifying an ablation pattern for a heart of a patient, the computing system comprising:
one or more computer-readable storage mediums storing computer-executable instructions that when executed control the one or more computing systems to:
identify a simulated cardiogram generated from a non-ablation pattern simulation of a model library of non-ablation pattern simulations, each non-ablation pattern simulation generated based on a computational model of the heart and a heart configuration that includes a simulated source location;
identify an ablation pattern and a simulated source location associated with the simulated cardiogram, the ablation pattern associated with an ablation pattern simulation generated based on a computational model of the heart, based on a heart configuration that includes a source location, and based on the identified ablation pattern, the identified ablation pattern identified based on a mapping of the identified simulated cardiogram to the identified ablation pattern; and
direct an ablation therapy for the patient based on the identified simulated source location and the identified ablation pattern; and
one or more processors for executing the computer-executable instructions stored in the one or more computer-readable storage mediums.
- 26. A method of treating a heart of a patient, comprising:
identifying a source location within the heart of the patient and an ablation pattern, the identifying based on ablation pattern simulations, each ablation pattern simulation based on a rotor location and an ablation pattern wherein the identifying is based on a patient cardiogram of the patient; positioning a neuromodulation device at a target site of the heart based on the identified rotor location; and applying energy based on the identified ablation pattern to the target site of the heart using the neuromodulation device.
- 31. A method of treating a patient, comprising:
identifying a source location of an arrhythmia within the heart of the patient and an ablation pattern by directing a computing system to:
identify a simulated cardiogram that is similar to a patient cardiogram of the patient, the simulated cardiogram generated from a non-ablation pattern simulation of a model library of non-ablation pattern simulations, each non-ablation pattern simulation generated based on a computational model of the heart and a simulated heart configuration that includes a simulated source location, each heart configuration of a simulation mapped to a simulated cardiogram generated based on the simulation; and
identify a simulated source location and an ablation pattern based on the identified simulated cardiogram, the simulated source location and the ablation pattern used in generating an ablation pattern simulation, the ablation pattern simulation generated based on the computational model of the heart, based on the heart configuration that includes the simulated source location, and based on the ablation pattern;
positioning a neuromodulation device at a target site based on the identified simulated source location; and applying energy based on the identified ablation pattern using the positioned neuromodulation device.
- 38. A method of treating a patient, comprising:
identifying a source location of an arrhythmia within the heart of the patient by directing a computing system to:
identify a simulated cardiogram that is similar to a patient cardiogram of the patient, the simulated cardiogram generated from a simulation of a model library of simulations, each simulation generated based on a computational model of the heart and a simulated heart configuration that includes a simulated source location, each heart configuration of a simulation mapped to a simulated cardiogram generated based on that simulation; and
identify a simulated source location of a simulated heart configuration used in generating the simulation from which the identified simulated cardiogram was generated;
positioning a neuromodulation device at a target site based on the identified simulated source location; and applying energy to the target site using the positioned neuromodulation device.
- 39. A method for generating a model library of simulations of electrical activations of a heart, the method comprising:
accessing simulated heart configurations that include a simulated source location and an ablation pattern; for each simulated heart configuration,
running a simulation based on the simulated heart configuration; and
designating the simulation as being successful when the simulation does not result in an arrhythmia.
