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Application US20200237679
Published 2020-07-30
Lipid Nanoparticle Compositions And Methods As Carriers Of Cannabinoids In Standardized Precision-metered Dosage Forms
This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process that encapsulate a high concentration of cannabinoids, and create standardized precision-metered dosage forms of cannabinoids; yielding an increase cannabinoid transport across hydrophobic mucosa; increase the bioavailability of the cannabinoid 2-fold to 8-fold, decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to illicit the same therapeutic effect compared to raw and non-encapsulated cannabinoids; where the nanoparticle dynamic structure reduces the adverse effects of cannabinoids; and enable safe more efficacious cannabinoid therapy.
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- 1. A drug delivery system comprising nanoparticle structures; wherein a single layer of essential phospholipids encapsulates liquid lipids and drug in each nanoparticle structure;
wherein the phospholipid content (weight/volume) of the nanoparticle structures is 5-30%; wherein the nanoparticle structures have a particle size distribution from 50 to 150 nm; and wherein the nanoparticle structures yield standardized precision-metered dose drug.
- 12. A method of drug therapy comprising treatment with the drug; wherein the drug is encapsulated in nanoparticle structures; wherein a single layer of essential phospholipids encapsulate liquid lipids and drug; wherein the nanoparticle structure has a particle size distribution from 50 to 150 nm; and wherein the nanoparticle structure yields standardized precision-metered dose drug.
