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AI Biotech/Diagnostics: Cardio
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Application US20180356403
Published 2018-12-13
Use Of Immune Repertoire Diversity For Predicting Transplant Rejection
Methods of assessing a graft recipient's predisposition to reject a transplant are provided. The risk of transplant rejection may be assessed in a subject prior to transplant, wherein subjects having a greater immune repertoire diversity prior to transplant are more susceptible to transplant rejection. Also, increases in immune repertoire diversity after transplant are indicative of transplant risk after. In another aspect, the presence or elevated abundance of immune elements comprising IGHV3-23 sequences are indicators of transplant rejection risk. In another aspect the scope of the invention encompasses methods of treating transplant rejection in a subject, by assessing transplant risk and administering immunosuppressive therapy in accordance with assessed risk.
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- 1. A method of predicting transplant risk in a subject, wherein the subject is prospective graft recipient, comprising the steps of:
obtaining a sample from the subject; assessing a measure of the subject's immune repertoire diversity by the sample; comparing the measured immune repertoire diversity to a predetermined threshold to determine the subject's risk of transplant rejection, wherein, if the subject's measured immune repertoire diversity is above the threshold, the subject is considered to have an increased risk of transplant rejection.
- 7. A method of assessing transplant rejection risk in a subject, wherein the subject is a graft recipient, comprising the steps of:
obtaining a sample from the subject at a first time point and a second time point; for each of the first and second time points, assessing a measure of the subject's immune repertoire diversity by the sample; comparing the measured diversity at the first and second time points, wherein a decrease in R diversity between the two time points is associated with an elevated risk of transplant rejection.
- 13. A method of assessing transplant risk in a subject, comprising
obtaining a sample from the subject; assessing the abundance of selected clonotypes comprising IGHV3-23 sequences in the sample; comparing the abundance of selected clonotypes comprising IGHV3-23 sequences to a predetermined threshold to determine the subject's risk of transplant rejection, wherein, if the subject's measured abundance of the clonotypes comprising IGHV3-23 sequences is above the threshold, the subject is considered to have an increased risk of transplant rejection and if the subject's measured abundance of the selected clonotypes comprising IGHV3-23 sequences is below the threshold value, the subject is considered to have a reduced risk of transplant rejection.
