| Abstract: |
Methods of assessing a graft recipient's predisposition to reject a transplant are provided. The risk of transplant rejection may be assessed in a subject prior to transplant, wherein subjects having a greater immune repertoire diversity prior to transplant are more susceptible to transplant rejection. Also, increases in immune repertoire diversity after transplant are indicative of transplant risk after. In another aspect, the presence or elevated abundance of immune elements comprising IGHV3-23 sequences are indicators of transplant rejection risk. In another aspect the scope of the invention encompasses methods of treating transplant rejection in a subject, by assessing transplant risk and administering immunosuppressive therapy in accordance with assessed risk. |
| Inventor: |
Sarwal, Minnie (San Francisco, CA, US); Sirota, Marina (Belmont, CA, US); Pineda San Juan, Silvia (Madrid, ES) |
| Applicant: |
The Regents of the University of California (Oakland, CA, US) |
| Face Assignee: |
N/A |
| Filed: |
2018-06-11 |
| Issued: |
2018-12-13 |
| Claims: |
20 |
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US20180356403
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1. A method of predicting transplant risk in a subject, wherein the subject is prospective graft recipient, comprising the steps of:
(5)
(3)
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7. A method of assessing transplant rejection risk in a subject, wherein the subject is a graft recipient, comprising the steps of:
(5)
(3)
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13. A method of assessing transplant risk in a subject, comprising
(5)
(3)
|
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