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Patent US10704066
Issued 2020-07-07
Neurotransmitters And Methods Of Making The Same
In an aspect, the disclosure provides methods for making neurotransmitters in a host organism. The neurotransmitters can be cannabinoids and derivatives of cannabinoids. The host cells can be microalgae, fungi or other host cells. In a related aspect, the disclosure provides host cells engineered to have biochemical pathways for making neurotransmitters such as cannabinoids.
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USPTO Full Text Publication >
- 1. A method, comprising the steps of: providing a Prototheca microalgae host cell wherein the Prototheca microalgae host cell comprises a first nucleic acid encoding a hexanoyl-CoA synthase from Cannabis sativa, a second nucleic acid encoding a 3,5,7-trioxododecanoyl-CoA synthase from Cannabis sativa, a third nucleic acid encoding an olivetolic acid cyclase from Cannabis sativa, and a fourth nucleic acid encoding a geranyl-diphosphate:olivetolate geranyltransferase from Cannabis sativa, wherein the first nucleic acid is operably linked to a control region, wherein the second nucleic acid is operably linked to a control region, wherein the third nucleic acid is operably linked to a control region, and wherein the fourth nucleic acid is operably linked to a control region, introducing the microalgae cell into a media wherein the media comprises a carbon source, culturing the microalgae cell in the media whereby a cannabinoid is made.
