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Application US20190038568
Published 2019-02-07
Delivery Systems
Disclosed herein are delivery systems including coated and uncoated yarns, yarn precursors, threads, fibers, and other substrates for the constant or near-constant release of active compounds, as well as methods for manufacturing such delivery systems. The yarns, yarn precursors, threads, fibers, and other substrates can include a cross-linked hydrophobic elastomer and an active compound. One or more coatings that are impermeable or substantially impermeable to the active compound may partially or fully occlude the yarn or substrate to control release rates of the active compound. The delivery systems may be used in a variety of applications, including the making of articles of clothing, textiles, and fabrics, and may be used in methods of treating various conditions and diseases.
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- 1.-34. (canceled)
- 35. A drug delivery system, comprising:
a core comprising: (i) a yarn; (ii) a polymeric matrix comprising a polymer, wherein the polymer is disposed on the yarn; and (iii) an active compound, wherein the active compound is dispersed in the polymeric matrix, and wherein the active compound is selected from the group consisting of methyl salicylate, ethyl salicylate, arnica oil, peppermint oil, menthol, lidocaine, benzocaine, capsaicin, nonivamide, niacinamide, cannabidiol, caffeine, and hydrocortisone.
- 49. An article of clothing comprising the drug delivery system of claim 1.
- 51. A method for manufacturing a system for delivery of an active compound comprising:
(a) preparing a mixture comprising:
(i) a monomer or an oligomer; and
(ii) an active compound;
(b) coating a yarn with the mixture; and (c) polymerizing the mixture to form a polymeric matrix by exposing the coated yarn to ultraviolet light.
