Application US20190038568

DELIVERY SYSTEMS
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US20190038568

1.-34. (canceled) (0)

35. A drug delivery system, comprising: (6) (4)

a core comprising:

(i) a yarn;

(ii) a polymeric matrix comprising a polymer, wherein the polymer is disposed on the yarn; and

(iii) an active compound, wherein the active compound is dispersed in the polymeric matrix, and wherein the active compound is selected from the group consisting of methyl salicylate, ethyl salicylate, arnica oil, peppermint oil, menthol, lidocaine, benzocaine, capsaicin, nonivamide, niacinamide, cannabidiol, caffeine, and hydrocortisone.

36. The drug delivery system of claim 35, wherein the polymer is selected from the group consisting of elastomers, polysiloxanes, polyurethanes, polyanhydrides, polyisobutylene, elastin, polyisoprene, chloroprene, neoprene, butyl rubber, styrene-butadiene rubber (SBR), nitrile rubber, epichlorohydrin rubber, fluoroelastomers, polyether block amides, ethylene-vinylacetate (EVA), poly(styrene-b-isobutylene-b-styrene), styrenic block copolymers, polyolefin blends, elastomeric alloys, thermoplastic polyurethanes (TPU), thermoplastic copolyesters, and thermoplastic polyamides. (0)

37. The drug delivery system of claim 35, wherein the yarn comprises a substrate selected from a metal, a ceramic, a polymer, a composite, a thread and a fabric. (0)

38. The drug delivery system of claim 35, further comprising a coating that is disposed on the core to form one or more coated segments and one or more non-coated segments, wherein the coating is substantially impermeable to the active compound. (6) (0)

40. The drug delivery system of claim 38, wherein the ratio of the length of the one or more coated segments to the length of the one or more non-coated segments is greater than one. (0)

41. The drug delivery system of claim 38, wherein the ratio of the length of the one or more coated segments to the length of the one or more non-coated segments is greater than four. (0)

42. The drug delivery system of claim 38, wherein the ratio of the length of the one or more coated segments to the length of the one or more non-coated segments is greater than nine. (0)

43. The drug delivery system of claim 38, wherein the one or more coated segments and the one or more non-coated segments alternate along a length of the yarn. (0)

44. The drug delivery system of claim 38, wherein the coating comprises a material selected from polyvinyl chloride (PVC), polypropylene, PTFE, polyvinylidene fluoride (PVDF), PMMA, shellac, polycarbonate, polybutylene terephthalate, epoxy, polyethylene terephthalate (PET), high-density polyethylene, celluloid, acrylonitrile butadiene styrene (ABS), polyimide, nylon, phenol-formaldehyde resin, and polystyrene. (0)

45. The drug delivery system of claim 38, wherein the coating comprises one or more coated segments comprising a first coating material and one or more coated segments comprising a second coating material. (0)

39. The drug delivery system of claim 35, wherein the system exhibits zero-order or near-zero-order release of the active compound. (0)

46. The drug delivery system of claim 35, further comprising an outer sheath disposed over the core. (1) (0)

48. The drug delivery system of claim 35, wherein the polymeric matrix and the active compound are extruded with the yarn. (0)

49. An article of clothing comprising the drug delivery system of claim 1. (1) (0)

51. A method for manufacturing a system for delivery of an active compound comprising: (3) (3)

(a) preparing a mixture comprising: (i) a monomer or an oligomer; and

(ii) an active compound;

(b) coating a yarn with the mixture; and

52. The method of claim 51, wherein, the active compound is selected from the group consisting of methyl salicylate, ethyl salicylate, arnica oil, peppermint oil, menthol, lidocaine, benzocaine, capsaicin, nonivamide, niacinamide, cannabidiol, caffeine, and hydrocortisone. (0)

53. The method of claim 51, wherein the polymeric matrix comprises a polymer selected from the group consisting of elastomers, polysiloxanes, polyurethanes, polyanhydrides, polyisobutylene, elastin, polyisoprene, chloroprene, neoprene, butyl rubber, styrene-butadiene rubber (SBR), nitrile rubber, epichlorohydrin rubber, fluoroelastomers, polyether block amides, ethylene-vinylacetate (EVA), poly(styrene-b-isobutylene-b-styrene), styrenic block copolymers, polyolefin blends, elastomeric alloys, thermoplastic polyurethanes (TPU), thermoplastic copolyesters, and thermoplastic polyamides. (0)

54. The drug delivery system of claim 51, wherein the yarn comprises a substrate selected from a metal, a ceramic, a polymer, a composite, a thread and a fabric. (0)

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Application US20190038568

DELIVERY SYSTEMS

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