Patent US10660865

Cannabidiol for the prevention and treatment of graft-versus-host disease
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US10660865

1. A method for preventing a graft-versus-host disease (GVHD) in a patient undergoing transplantation, comprising the step of administering to said patient, a non-psychoactive composition comprising cannabidiol in a dose of about 5 mg to about 600 mg, thereby preventing a GVHD. (8) (0)

2. The method according to claim 1 wherein said GVHD is acute GVHD. (0)

3. The method according to claim 1 wherein said GVHD is chronic GVHD. (0)

4. The method according to claim 1, wherein said undergoing transplantation comprises having underwent or being destined to undergo an allogeneic hematopoietic stem cell transplantation. (2) (0)

5. The method according to claim 1, wherein said administering comprises administering 14 days prior to transplantation. (0)

6. The method according to claim 1, wherein said administering comprises administering 1 to 30 days after transplantation or 7 days to 180 after transplantation. (0)

7. The method according to claim 1, further comprising administering at least one additional therapeutic agent. (0)

8. The method according to claim 1, further comprising administering cyclosporine. (0)

9. The method according to claim 1, further comprising administering: tacrolimus, methotrexate, mycophenolate mofetil, sirolimus, ATG, imatinib a TKI, azathioprine, pentostatin, thalidomide, retinoids, anti-CD20 molecule, anti-CD52 molecule, ECP, a corticosteroid, a mesenchymal stem cell, or any combination thereof. (0)

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Patent US10660865

Cannabidiol for the prevention and treatment of graft-versus-host disease

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