Application US20200061004

COMPOSITIONS AND METHODS FOR DELIVERING CANNABIDIOL AND KETONE BODIES
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US20200061004

1. A composition comprising: (6) (2)

a ketone body component selected from beta-hydroxybutyrate (BHB) salts, BHB esters, BHB acid, acetoacetate salts, acetoacetate esters, acetoacetic acid, and combinations thereof; and

a cannabidiol (CBD) component.

3. The composition of claim 1, further comprising one or more additional cannabinoid compounds derived from the cannabis plant. (0)

5. The composition of claim 1, further comprising one or more components selected from 1,3-butanediol, a fatty acid, an ester of the fatty acid a medium chain fatty acid, an ester of the medium chain fatty acid, a short chain fatty acid, or an ester of the short chain fatty acid. (0)

7. The composition of claim 1, wherein the composition is provided in solid or powder form. (0)

8. The composition of claim 1, wherein the composition is provided in liquid form. (0)

9. The composition of claim 1, wherein the composition is in a dosage form that provides from about 0.5 grams to about 50 grams, or about 1 gram to about 40 grams, or about 2 grams to about 30 grams, or about 3 grams to about 25 grams, or about 4 grams to about 20 grams, of the ketone body component and provides about 3 mg to about 1 gram, or about 10 mg to about 600 mg, or about 15 mg to about 400 mg, or about 20 mg to about 300 mg, of the CBD component. (0)

11. The composition of claim 1, further comprising a pharmaceutically or dietetically acceptable carrier. (0)

2. (canceled) (0)

4. (canceled) (0)

6. (canceled) (0)

10. (canceled) (0)

12. A composition comprising: (1) (3)

a ketone body component selected from beta-hydroxybutyrate (BHB) salts, BHB esters, BHB acid, acetoacetate salts, acetoacetate esters, acetoacetic acid, and combinations thereof; and

a cannabidiol (CBD) component,

wherein the composition is in a dosage form that provides a unit dose of about 0.5 grams to about 50 grams of the ketone body component and a unit dose of about 3 mg to about 1 gram of the CBD component.

13. The composition of claim 12, wherein the composition includes a ratio of the ketone body component to the CBD component in a range about 6:1 to about 6,000:1 by weight, or in a range of about 9:1 to about 4,000:1 by weight, or in a range of about 14:1 to about 2,000:1 by weight. (0)

14. (canceled) (0)

15. (canceled) (0)

16. A method for administering ketone bodies and cannabidiol (CBD) to a mammal, comprising: (10) (2)

administering a ketone body component selected from beta-hydroxybutyrate (BHB) salts, BHB esters, BHB acid, acetoacetate salts, acetoacetate esters, acetoacetic acid, and combinations thereof; and

administering a CBD component.

17. The method of claim 16, wherein administering comprises administering a daily dose of about 0.5 grams to about 50 grams of the ketone body component and a daily dose of about 3 mg to about 1 gram of the CBD component. (0)

19. The method of claim 16, wherein method provides one or more of homeostasis promotion, neuroprotection, memory enhancement, an anxiolytic effect, an anti-depressant effect, an anti-inflammatory effect, an analgesic effect, an antioxidant effect, blood pressure modulation, heart rate modulation, an anti-tumorigenic effect, a longevity promoting effect, or sleep promotion. (0)

20. The method of claim 16, wherein the CBD component functions to counteract serotonin reduction associated with administration of the ketone body component. (0)

21. The method of claim 16, wherein the method promotes one or more of weight loss, fat loss, appetite suppression, or fat browning, wherein fat browning increases lipolysis. (0)

22. The method of claim 16, wherein the ketone body component increases the pharmacokinetic utilization of the CBD component relative to pharmacokinetic utilization of the CBD component in the absence of the ketone body component. (0)

23. The method of claim 16, wherein the method accelerates the production of endogenous ketones in the subject as a result of increased availability of ketone body precursors. (0)

24. The method of claim 16, wherein the method induces sustained ketosis in the mammal with reduced symptoms of hypoglycemia and/or keto flu relative to a ketone body composition omitting CBD. (0)

25. The method of claim 16, wherein the ketone body component enhances effectiveness of the composition at least in part as a result of molecular signaling. (0)

26. The method of claim 16, the method enhancing function of the endocannabinoid system in a mammal. (0)

27. The method of claim 16, wherein administering comprises one or more of ingestion, intragastric, injection, topical, inhalation, oral mucosal, rectal, vaginal, or parenteral. (0)

18. (canceled) (0)

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Application US20200061004

COMPOSITIONS AND METHODS FOR DELIVERING CANNABIDIOL AND KETONE BODIES

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