Pharmacodynamic Model For Determining Last Use Of Inhaled And Oral Cannabis Products
The present invention provides a method for determining recent use of cannabis in human subjects, the method comprising collecting samples of whole blood separated in time utilizing a device that collects and stores capillary blood for LC-MS/MS analysis. In particular embodiments, the method is used by law enforcement personnel to collect evidence in driving under the influence investigations. In some embodiments, the method is utilized by employers in routine monitoring of workplace drug policy compliance among employees and in workplace accident investigations.
Claim CLM-00001. 1. A method for determining recent use of cannabis in a subject, the method comprising collecting two or more whole blood samples separated in time by approximately 20 to 30 minutes, analyzing them for Δ9-THC, Δ9-THC metabolites, and other cannabinoids, computing specific pharmacokinetic parameters, and then evaluating the results based on the criteria of at least six parameters associated with the recent use of cannabis.
Claim CLM-00010. 10. A kit comprising blood collection devices, sample tubes, gloves, sample tube labels, and sample shipping container.
Claim CLM-00015. 15. A method for determining recent use of other drugs of abuse, for example, illegal synthetic cannabinoids, methamphetamine, opiates, benzodiazepines, barbiturates, and cocaine, the method comprising collecting two or more whole blood samples separated in time by approximately 20 to 30 minutes, analyzing them for key drug molecules and metabolites, computing specific pharmacokinetic parameters, and then evaluating the results based on the criteria of at least six parameters associated with the recent use of each respective drug compound.
